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In the case of the nonbenzodiazepines, zaleplon may be the safest in terms of next-day sedation, and − unlike zolpidem and zopiclone − zaleplon has been found to have no association with increased motor vehicle accidents even when taken for middle-of-the-night insomnia due to its ultrashort elimination half-life.

Many of these compounds are subtype selective providing novel anxiolytics with little to no hypnotic and amnesiac effects and novel hypnotics with little or no anxiolytic effects.

The paper found that there is little research into hypnotics that is independent from the drug manufacturers.

Also of concern was the lack of focus in industry-sponsored trials on their own results showing that use of hypnotics is correlated with depression.

However, data is limited so no conclusions can be drawn.

Data is also limited into the long-term effects of nonbenzodiazepines.

Further research into the safety of nonbenzodiazepines and long-term effectiveness of nonbenzodiazepines has been recommended in a review of the literature.